Journal article
What happens after menopause? (WHAM): A prospective controlled study of sleep quality up to 12 months after premenopausal risk-reducing salpingo-oophorectomy
M Hickey, KM Moss, EO Krejany, CD Wrede, SM Domchek, J Kirk, A Brand, A Trainer, GD Mishra, FC Baker
Gynecologic Oncology | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2021
Abstract
Objective: Sleep difficulties impair function and increase the risk of depression at menopause and premenopausal oophorectomy may further worsen sleep. However, prospective data are limited, and it remains uncertain whether Hormone Therapy (HT) improves sleep. This prospective observational study measured sleep quality before and up to 12 months after risk-reducing salpingo-oophorectomy (RRSO) compared to a similar age comparison group who retained their ovaries. Methods: Ninety-five premenopausal women undergoing RRSO and 99 comparisons were evaluated over a 12-month period using the Pittsburgh Sleep Quality Index (PSQI). Results: Almost half reported poor sleep quality at baseline. Overall..
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Grants
Awarded by Royal Melbourne Hospital
Funding Acknowledgements
This research was supported by Register4 through its members' participation in research and/or provision of samples and information (register4.org.au). In Australia this study was supported by public funding provided by the National Health and Medical Research Council of Australia (NHMRC; Grant #APP1048023), and by philanthropic funding provided by The Royal Women's Hospital (Melbourne, Australia), The Women's Foundation (Melbourne, Australia), Australia New Zealand Gynaecological Oncology Group (ANZGOG, Sydney, Australia) and the Westmead Hospital Familial Cancer Service (Sydney, Australia). In the USA this study was supported by philanthropic funding provided by the Basser Center for BRCA and the Susan G. Komen organization (Grant #SAC150003). None of the funding agencies had a role in the design or conduct of the study, nor the collection, management, analyses or interpretation of the data, nor the preparation or approval of this manuscript. MH is supported by a NHMRC Practitioner Fellowship (ID #1058935). SMD is supported by the Susan G. Komen organization. GDM is supported by a NHMRC Principal Research Fellowship (ID #APP1121844). We are grateful to the women who generously gave of their time to participate in this study and to the following people who assisted with participant recruitment and study management: Orla McNally and Deborah Neesham (The Royal Women's Hospital, Melbourne, Australia), Lesley Andrews and Leon Botes (Prince of Wales Hospital, Sydney, Australia), Bettina Meiser (University of Sydney, Sydney, Australia), Mariana De Sousa (University of Technology, Sydney, Australia), Heather Symecko (University of Pennsylvania, Philadelphia, USA), Sue Shanley, Gillian Mitchell and Mary Shanahan (Peter MacCallum Cancer Centre, Melbourne, Australia), Trevor Tejada-Berges and Masako Dunn (Chris O'Brien Lifehouse, Sydney, Australia), L. Jane McNeilage and Marion Harris (Monash Medical Centre, Melbourne, Australia), Geoffrey Lindeman (The Royal Melbourne Hospital, Melbourne, Australia), Peter Grant (Mercy Hospital for Women, Melbourne, Australia) and Nipuni Gamage (University of Melbourne, Melbourne, Australia). Thanks also to Mary-Ann Davey (Monash University, Melbourne, Australia) and Sabine Braat (University of Melbourne, Melbourne, Australia) for the provision of preliminary advice and support with statistical methodology, modelling and analysis.